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In the developed world, PEM more commonly occurs secondary to a chronic disease that interferes with nutrient metabolism, such as inflammatory bowel disease, chronic renal failure, or cancer (24)

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Dietary carbohydrate intake affects insulin resistance, inflammation, weight regulation, and hormonal balance, critical components of PCOS pathology

The compounds are actively extruded from cells by ATP7A and ATP7B copper transporters and by multidrug resistance protein 1 (MRP1/ABCC1)

doi: 10.1038/ni1202-1129

Deficiency in macronutrients and/or micronutrients causes impairment of immune function, which can be reversed by nutrient repletion