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Increasing agrin function antagonizes muscle atrophy and motor impairment in spinal muscular atrophy

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Specifically, miR-92a-2-5p increases NFATc1 levels by suppressing IRF8, and miR-373-3p reduces Runx2 expression [244]

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In addition to the conserved nucleotide site, there are two conserved residues in the N-terminal domain, a histidine and an aspartate that are involved in catalysis