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The Royal Society of Public Health thinks the same (8), it said: nicotine by itself is fairly harmlessnot too dissimilar to caffeine addiction . In their 2013 report titled Tobacco Harm Reduction and Nicotine Containing Products (9), Cancer Research UK stated that nicotine, beyond its mildly addictive properties outside of cigarettes, has no established short- or long-term danger

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So it could be that some are safer or more harmful than others

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"An Oral History of Transformers Director Michael Bay"