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It has been shown that MnSOD activity depends on the intracellular concentration of manganese (Feng and Wang 2020), as mentioned earlier

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doi: 10.3390/antiox8110557

Timing of administration is important, with doses given 3060 minutes before meals to improve chewing and swallowing, or before bedtime to reduce morning weakness

Outlook Inhalable biomaterials have transformed lung protection and medication delivery

A recent review highlighted concerns with IV use, including rare anaphylaxis and potential hepatotoxicity (PMC narrative review)