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The authors suggest that this work provides evidence of a useful biomarker, CD8 T-cell dysfunction reminiscent of T cell exhaustion, that may assist diagnosis and have utility for tracking disease outcome during therapy, including response to a potential new treatment

Remember that you will most likely need one shot per week and, depending on the amount of weight you desire to lose and the time it will take you, you will most likely need several injections

doi: 10.1038/nature08778 49 HoffmanW

Positive controls are known mutagens 2-nitrofluorene and 4-nitroquinoline-N-oxide for the assay without S9 and 2-aminoanthracene in the assay with S9

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Oikawa T, Onozawa C, Inose M, Sasaki M (1995) Depudecin, a microbial metabolite containing two epoxide groups, exhibits anti-angiogenic activity in vivo