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Latz JE, Chaudhary A, Ghosh A, Johnson RD

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intraperitoneal routes in BALB/c and C57BL/6 mice found route-dependent differences in behavioral outcomes, consistent with distinct pharmacokinetic profiles[15] Oral bioavailability is not established for Selank given its peptide nature Metabolism & Elimination Biodegradation studies using evenly tritium-labeled Selank identified the major metabolic products in blood plasma as the pentapeptide TKPRP, the tripeptide TKP, and the dipeptides RP and GP[14]

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Participants with renal impairment were recruited before those with normal renal function to help ensure similarity across groups in age and body weight