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Furthermore, ALCAR is important for optimal metabolism and cellular function in the brain, spinal cord and peripheral nerves

In vivo studies have further demonstrated that PDA NPs can alleviate puncture-induced disc degeneration by suppressing ferroptosis and restoring antioxidant defenses, offering a novel therapeutic strategy for IDD that directly targets ferroptosis-related damage at the mitochondrial level (94,95)

6C, middle ), which was reversible after a washout of 510 min ( Fig

All forms converge on the same cellular pathway

The translatability of ferroptosis-targeted therapies from current models to humans is thus uncertain

Abstract Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling