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More recently, Lucas et al

Therefore, excess APAP is predominantly metabolized by CYP2E1, leading to an increased NAPQI output, which may result in the depletion of liver GSH stores

Su YL, Ng CT, Jan YH, Hsieh YL, Wu CL, Tan KT

Epub 2023 Nov 28

Glutathione is an important antioxidant present in the cells of the human body

(3) the more effective combination partner, phenformin, has been linked to increased lactic acidosis in patients 80 , which is to be avoided in patients with CRC