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CagA directly induces a severe inflammatory response in the stomach with elevated levels of IL-37 (Yucel, 2019

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(Haapasalo et al., 2003) analyzed 433 cases of astrocytoma and showed that the expression of thioredoxin reductase-1 (TrxR1) was upregulated in more than 66% of cases, which was significantly associated with relatively high proliferative activity and poor prognosis

This increase in fission, however, has a protective effect in this context because it sensitizes ectopic endometrial cells to apoptosis by promoting release and activation of the mitochondrial serine protease HtrA2/Omi, which cleaves and inactivates inhibitor-of-apoptosis proteins (IAPs), thereby weakening a major anti-apoptotic defense and reducing lesion invasion and migration ( 4.3 Mitochondrial autophagy and endometriosis Mitochondrial autophagy, or mitophagy, is a highly selective, damage-responsive clearance process that identifies, labels, and removes dysfunctional, depolarized, or aged mitochondria while preserving the healthy mitochondrial network