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The traditional Japanese herbal medicine hachimijiogan elicits neurite outgrowth effects in PC12 cells and improves cognitive in AD model rats via phosphorylation of CREB

Another strategy is utilizing PARP inhibitors, which resulted in rescuing NAD + levels and decreasing A aggregation in brain samples of AD flies, however, this study did not include any measurements of mitochondrial function 275

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On the other hand, one study reported that the adenoviral overexpression of TGFb1 in the striatum led to a decrease in the number of midbrain dopaminergic neurons in MPTP-injected mice in vivo [25]