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Description

In the arterial wall it was demonstrated that VDR activation enhanced eNOS activity, improved vascular relaxation and decreased oxidative stress [49]

Gut (2010) 59(10):14105

Caution is advised in pregnant women, as fetotoxic effects have been documented in rats and rabbits at doses exceeding 0.5 mg/kg, though no teratogenic effects have been observed (Jiangbo et al., 2009)

Recent studies suggest that its cuproptotic effects may extend beyond reliance on the mitochondrial protein FDX1

Based on homology with other class C GPCRs (mGluRs and GABA B Rs), multiple studies propose similar activation mechanisms for the sweet receptor (Kunishima et al., 2000