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One major hurdle in drug development is an incomplete understanding of the underlying mechanisms that drive A plaques and tau-containing neurofibrillary tangles (NFTs) in the brain which may begin decades prior to cognitive decline (911)

The cause of multiple sclerosis is uncertain

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[DOI] [PubMed] [Google Scholar] 20.Maniatis NA, et al

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Anesthesiology 93(3):619628 Ltsch J, Skarke C, Schmidt H, Rohrbacher M, Hofmann U, Schwab M et al (2006) Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites