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Malabsorption Issues- Certain medical conditions, such as pernicious anaemia or gastrointestinal disorders, can interfere with the bodys ability to absorb B12 from food

Hematocrit and reticulocyte counts should be repeated daily from the 5th to 7th days of therapy and then frequently until the hematocrit is normal

Look out for fatigue , weakness , and neurological changes like numbness

The standard schedule is a starting point, not a strict rule The 2024 NICE guideline NG239 on B12 deficiency in over 16s makes an important point: the optimal route, dose and frequency of B12 replacement have never been firmly established, and have often followed custom and historical practice

Not everyone needs to reach the maximum dose

Others choose every one to two weeks