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Description

In xenograft tumor models, the inhibitor showed selective activation in hypoxic regions, resulting in significant tumor growth suppression with minimal systemic toxicity (286, 287)

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Bromodomain and extraterminal (BET) protein inhibition sensitize BRAFV600E colorectal cancer to standard targeted therapies

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Protected amino acids are added individually in alternating steps of coupling and deprotection until the full peptide chain is built

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2) antioxidative action attributable to a direct interaction with free radicals, an indirect effect as a precursor to cysteine which is required for glutathione biosynthesis, and a replenishment of thiol pools that is central to redox regulation and control

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GC content elevates mutation and recombination rates in the yeast Saccharomyces cerevisiae

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However, even if BHZ reacts with the LTQ cofactor on other LOX enzymes, the assay can still be used to define the localization of active LOXs in situ

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