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113 SumnerM.FeyM.NobleA

Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis

During the study period, six subjects withdrew (withdrawal of consent or loss to follow-up), ten subjects withdrew at the investigator's discretion (hair perm, dyeing, etc.), and one subject dropped out due to an adverse reaction

Precautions Before beginning treatment with METHYLCOBALAMIN+PYRIDOXINE HCL+NICOTINAMIDE, inform your doctor if you are already taking any prescription or over-the-counter medications, or herbal supplements