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Consequently, vector-mediated overexpression of MTTP in the Fatty Liver Shionogi mice decreased liver triglycerides and improved NASH [123]

Elevated levels of ROS increase the incidence of mtDNA mutations [41], and the accumulation of induced mtDNA mutations as well as restricted DNA repair capacity, together with errors during replication, lead to increased DNA damage and chromosome damage [42, 43]

10.1080/01480545.2023.2291983 59 DixitR

In clinical studies, treatment with recombinant IGF-1 improved renal function in patients with moderate renal insufficiency or end stage renal disease (ESRD), as evidenced by increased GFR, lower plasma creatinine and BUN levels, and enhanced inulin clearance