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We also acknowledge the Curtin Medical School and The Curtin Health Innovation Research Institute for research support and provision of excellent research facilities

Given its high usage and availability as an over-the-counter analgesic, a systematic review of paracetamols efficacy and tolerability in individual conditions is warranted ( On the whole, although there is no direct evidence in COVID-19 patients, PAC is likely to promote GSH depletion, especially in those population groups at higher risk ( The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere ( Counterintuitively, however, the same precautionary principle has not been applied to PAC itself, and the risks of developing severe COVID-19 associated to the reduction of GSH might be far higher than the benefits derived from discouraging the use of NSAIDs or steroids

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Campelo, S