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The active form of MAPKKK phosphorylates MEK1/2 (MAPKK), which in turn phosphorylates ERK1/2 (MAPK), favoring its nuclear translocation and activation of target transcription factors (90)

For comparison between treatment groups, the null hypothesis was tested by either a single-factor analysis of variance (ANOVA) for multiple groups or an unpaired t-test for two groups, and the data are presented as mean SEM

Notably, different regulated cell death pathways are functionally complementary rather than mutually exclusive during periodontitis progression

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10.1016/j.molcel.2018.10.042 117 GerhardD