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doi: 10.1038/nature00779 114 LiuXNovosedlikNWangAHudsonMLCohenILChudleyAEet al

Furthermore, intestinal I/R injury can activate the vagus nerve, transmitting signals to the brain that influence neuronal activity and cognitive function, and alter gut microbial metabolite production, such as short-chain fatty acids (SCFAs), thus affecting neuronal signaling and cognitive processes (Wu et al., 2021