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This is of particular interest to both of us as selenium is involved as part of GSH peroxidases

Figure 6 Klotho Regulation and GH Secretion To date, it has not been clearly established how klotho secretion is regulated, although the fact that the kidneys are the main source of klotho suggests that hormones and factors involved in mineral homeostasis play a role in this regulation

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When deficient, animals can have reduced appetite and growth rates, ill thrift, infertility, and reduced wool and milk production