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Additionally, luteolin treatment downregulated ALOX15 and ACSL4 expression while upregulating SLC7A11 and GPX4, suggesting that luteolin-mediated ALOX15 inhibition alleviates ferroptosis in 16HBE cells ( Fig

FIGURE 1 Additionally, measurements of the Se content in both organs were made across all groups

In particular, back in 1996 Przedborski and colleagues indicated that GSH peroxidase activity is reduced in a specific brain region affected in ALS, the precentral gyrus, suggesting that the observed deficit could be involved in the oxidative damage observed in sporadic ALS [102]

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Other studies have shown that serum stimulation in an in vitro environment is able to cause an increase in mitochondrial ROS within GSCs and modulate differentiation signalling pathways in GSCs

L-Theanine enhances systemic antioxidant defense Relative to the model group, L-theanine treatment significantly decreased malondialdehyde (MDA) levels in the skin, liver, and serum (Fig