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We worry about the drug causing hemolysis [the breakdown of red blood cells] in people who have congenital deficiency of G6PD, says Charles Abrams, MD, director of the Penn-CHOP Blood Center in Philadelphia

10.14719/pst.2021.8.2.969 111 TannaI

one or more amino acid substitutions may be made within the framework regions, and, preferably, the amino acid substitutions improve binding of the antibody to its antigen