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In summary, 25-OHC, NRF2, SPY1, and MPO regulate neuronal ferroptosis and lipid peroxidation, thereby participating in the pathological development of ALS

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HO-1 was involved in the protective effect of telmisartan against DN, and the mRNA levels regulation of Nrf2 and HO-1 indicated that telmisartan had a regulatory effect on apoptosis besides anti-inflammation and anti-oxidation [153]

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doi: 10.1186/s13045-018-0645-x 117 SmithP

The results indicate a protective role of GSTP1 by enhancing GSH-conjugation, which might lead to a reduced protein modification, and suggest a second protective role by interfering with the unfolded protein response, thereby preventing apoptosis