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Although initially activated to buffer metabolic stress, the PINK1-Parkin pathway becomes suppressed under chronic overload, such as prolonged palmitate exposure, resulting in dysfunctional mitochondria, heightened oxidative stress, and activation of the NLRP3 inflammasome

Effects of edible oils with different N-6/N-3 pufa ratios on articular cartilage degeneration via regulating the nf-Kb signaling pathway