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"Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme"

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Lipoic acid might be able to increase glutathione synthesis in aged rats by up-regulating the expression of -glutamylcysteine ligase (-GCL), the rate-limiting enzyme in glutathione synthesis (31), and by increasing cellular uptake of cysteine, an amino acid required for glutathione synthesis (32)