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In summary, the development of pharmacological agents that promote itaconate production could potentially mitigate pathological inflammatory responses and prevent severe lung injury associated with TB progression

Statistical Analysis Sample size calculations were performed at the beginning of this exploratory trial ( n = 40)

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Gclc is required for T cell-independent and -dependent B cell immune responses Next, we aimed to understand how the metabolic perturbations caused by B cell-specific Gclc ablation impinge on immune responses and in particular how the impaired mitochondrial metabolism affects the antibody response

In another study [198] CdSe nanoparticles capped with a lipophilic phosphine were incubated with a dimeric radical probe consisting in a mercaptoacetic disulphide unit linked to two TEMPO-derived units