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Through ionic mechanisms such as currents generated by the voltage-dependent sodium (Nav) channel isoform Nav1.6, hyperpolarization-activated currents, and persistent inward currents, MTNs generate sustained and burst firing that regulate masticatory rhythm and jaw-jerk reflex timing

The Role of Colchicine in Atherosclerosis: From Bench to Bedside

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Main clinical impact of these technologies is an early identification of subclinical neuropathy that allows prompt implementation of intensive glycemic control, lifestyle interventions and neuroprotective therapies, which in turn has been shown to slow DPN progression and reduce incidence of foot ulcers and falls

Timing: Inject at a consistent time and rotate injection sites systematically