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Most ASMs that are presently available seek to target seizures rather than epilepsy pathophysiology, and they work by decreasing neuronal excitability

Seeking Professional Advice While self-management offers benefits, sometimes professional guidance is necessary

Autophagy 6(7):955957

Aldose reductase, still a compelling target for diabetic neuropathy

[DOI] [PMC free article] [PubMed] [Google Scholar] Eberle D., Clarke R., Kaplowitz N

When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)