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On other hand, arsenic-based compounds, with arsenic trioxide as the prototype, have already been approved by the FDA as a gold standard differentiation therapy to acute promyelocytic leukemia (APL) that is refractory to conventional therapies [133]

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29,31 Selenium depletion reflects reduced synthesis and secretion of selenoprotein P during systemic inflammation, redistribution of selenium to target tissues, and impaired hepatic function