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doi:10.1096/fj.02-0847fje

The redox signal transduction cascade is a highly complex and coordinated system involving the generation of reactive oxygen species, the oxidation of redox-relay molecules or direct oxidation of sensor molecules with thiol switches like Kelch-like ECH-associated protein 1 (Keap1), and effector molecules that change activity, localization, protein-protein interactions, or protein turnover in response to the redox signaling cascade [6, 7]