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Although apoptosis is an essential prerequisite in maintaining the population of Leydig cells and testosterone levels 50 increased apoptosis leads to decline in testosterone production, which may increase germ cell apoptosis and the possibility of infertility 51

Methods : A systematic review of the literature was performed in alignment with the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)

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We found that the deficiency of deglutamylases CCP1 or CCP5 leads to a highly reduced and diffused signal of LCA5, suggesting that the bulge region is lost, thus preventing membrane disc formation and presumably causing photoreceptor death (Figs

Gonzalez, C

doi: 10.3390/ijms26136456, [DOI] [PMC free article] [PubMed] [Google Scholar] Wu Q., Wang W., Huang Z., Lin X., Yao M., Cai C., et al