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While this manuscript was in preparation, a different group independently reported the role of R08E5.3 in DTT resistance and isolated a group of 10 different mutations in the same methyltransferase gene [10]

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After 28 days, discard and open a new vial

ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice

Gane E, Locarnini S, Lim TH, Strasser S, Sievert W, Cheng W, et al

These mechanisms lead to the failure of traditional treatments, exacerbating the prolongation of treatment duration, the increase in mortality rate and the spread of drug-resistant bacteria