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This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

Erdman J, Oria M, Pillsbury L, editors

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Cagrilintide adds a fourth channel that specifically enhances satiety signaling through brainstem amylin receptors