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Although less severe, the osteocyte-specific igf-1 knockouts showed a significant reduction in growth plate length that was attributed to the decrease in the length of the hypertrophic zone with no abnormalities in the proliferative zone ( Table 1 provides a summary of skeletal phenotypes of the various igf-1 and igf-1r knockouts of relevance to bone

J Pharm Biomed Anal 30:331339 Pokorny T, Preller KH, Kraehenmann R, Vollenweider FX (2016) Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience

Although this is currently theoretical, the deposition of alpha-synuclein aggregations like those found in the brain have been found in the enteric nervous system

Weindel et al., 2022)

10.1016/j.cell.2012.01.006 84

replacement of the acidic residues Asp and Glu