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Clinical trials showed that AOD-9604 has no effect on IGF-1 levels and does not interfere with glucose metabolism, making it compatible with various metabolic protocols

Thus, trigonelline might be an interesting therapeutic strategy as an NAD + modulator to explore in sarcopenia and possibly other chronic conditions

due to ageing or through acid-lowering medication), or bariatric surgery, lack of pancreatic enzymes, small intestinal bacterial overgrowth, certain intestinal parasites or dysfunction of the small intestine (e.g

This creates effects that translate into antidepressant, anxiolytic, and neuroprotective actions in animal models

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