Our lab has discovered that nuclear factor of activated T cells 1 (NFAT1), as a novel regulator of the MDM2 oncogene, directly binds to the MDM2 P2 promoter, enhancing MDM2 transcription independent of p53 (Zhang et al., 2012)
10.1002/mds.26424 141 Pozo DevotoV
PLoS One 3:e1944, PMID: 18398470 Janky R, Ogita K, Pasqualotto BA, Bains JS, Oja SS, Yoneda Y, Shaw CA (1999) Glutathione and signal transduction in the mammalian CNS
This effect lets you train harder and longer without fatigue, increasing your workout productivity and helping you break past performance plateaus.
Another approach is the A injections, where synthetic or purified A protein is injected into the brains of animals, usually rodents, 2023 leading to amyloid plaque formation and neuroinflammation, mimicking aspects of Alzheimers pathology
Aerobic Exercise: (Running, Cycling, Swimming): Supports heart and lung health while promoting beneficial gene expression linked to endurance and longevity.18 Strength Training: (Weight Lifting, Bodyweight Exercises): Helps support muscle-building gene regulation and healthy aging.19 High-Intensity Interval Training (HIIT): Short bursts of intense exercise support genes that regulate metabolism and fat burning.18 Yoga & Meditation: Can support healthy gene expression and relaxation, benefiting mental and physical health.20 Combining Diet and Exercise for Maximum Impact A combination of an epigenetics diet and regular exercise provides the best results for overall health
