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[6] [8] Estradiol cypionate is contraindicated during pregnancy because exogenous estrogen has no therapeutic role in gestation and in utero exposure could theoretically disturb fetal endocrine development or contribute to structural anomalies, although robust human teratogenicity data are limited

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But there are also studies that did not find or doubt this difference

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If the person is a woman, they will need to let their doctor know if they are pregnant or plan to become pregnant in the near future