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Use of SGLT2 inhibitors vs GLP-1 RAs and anemia in patients with diabetes and CKD

Comprehensive preclinical safety evaluations across multiple animal models demonstrate favorable tolerability profiles with excellent safety margins for investigational research applications

However, recent yeast-two-hybrid and bimolecular fluorescence complementation assays demonstrated that the BolA domain allows SufE1 to interact with monothiol glutaredoxins (GRXs), including plastid-targeted GRXS14 and GRXS16 (Couturier et al., in vitro experiments showed that the binding of GRXs promotes the deglutathionation of SufE1, and thereby facilitates the activation of NFS2 by deglutathionated SufE1 (Couturier et al., Full-length SufE2 and SufE3 have a plastid transit peptide and a SufE domain (Figure 3)

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L., Sailaja, E., Rao, A