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Numerous compounds that activate NRF2 through various mechanisms and structural compositions have been identified ( Pharmacological activation of NRF2: KEAP1-inhibitors Thus far, the most common class of NRF2-activators mimic the inhibition of NRF2s cytoplasmic negative regulator KEAP1, an adaptor protein for the CUL3/RBX1 E3 ubiquitin ligase complex, to prevent NRF2 proteasomal degradation (Kobayashi et al., 2004)

E = Standard Reduction Potential E = Standard Reduction Potential at pH 7 and 25C

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A high plant gain individual will show a comparatively big change in PaCO2 for a given change in minute ventilation, conversely, a poor plant gain individual will see a lesser change in PaCO2

Poon DC, Ho YS, Chiu K, Wong HL, Chang RC

L., Pan, Y., Short, J