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doi: 10.4155/fmc.14.93 33 OjedaP

Causal inference in drug discovery and development

This minimizes any potential interaction

The FDR was calculated using a subset of false-positive proteins expected not to be labeled by LaccID: nucleus and cytosol proteins that werenot annotated with terms related to the cell surface, Golgi or membrane (Supplementary Table 4)

Stalla F, Armandi A, Marinoni C, Fagoonee S, Pellicano R, Caviglia GP

In addition, inhibitors of the enzyme glutaminase (GLS) that converts glutamine to glutamate, which is subsequently transformed to GSH via the glutamatecysteine ligase complex, efficiently induce cancer cell death through dysregulation of their antioxidant system 72