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Labels such as psychogenic or psychosomatic are applied by doctors, in part, because of a statistical correlation with higher levels of depression and anxiety.[ref] However, the physiological and cellular changes in people with chemical sensitivities are measurable, statistically significant, and visible, strongly suggesting a physiological cause rather than a psychological cause.[ref][ref] On the other hand, there are several clinical trials using specific solvents or chemical odors that found no statistical change in measured parameters (e.g

P-gp, an efflux transporter, actively pumps out PTX as a substrate through an ATP-dependent mechanism, thereby mediating multidrug resistance and compromising the antitumor efficacy of PTX 33,34

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