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When sleep-deprived, people are more likely to catch colds, experience slower recovery from illnesses and injuries, and respond less effectively to vaccines

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Moreover, studies using animal models where gut permeability is altered because of the direct or indirect genetic or pharmacological manipulations have demonstrated diverse effects on mucosal immune homeostasis and inflammation, including immune adaptation and resistance to colitis

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However, a mini-review discusses how HBV reactivation poses a significant clinical challenge, especially in patients undergoing immunosuppressive therapies, including monoclonal antibodies

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