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Further investigation into the testicular microenvironment using a co-culture system of senescent TM3 Leydig cells and GC-1 spg spermatogonia revealed that H2O2-induced senescent TM3 cells secreted increased levels of SASP factors, particularly IL-6 and TGF-

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Researchers also noted a lower incidence of disease in this group

In addition to RSL3, other synthetic small molecules, including DPI7, DPI, JKE1674, and JKE-1716, can inhibit GPX4 activation (26)

Cangui-Panchi SP, acato-Toapanta AL, Enrquez-Martnez LJ, Salinas-Delgado GA, Reyes J, Garzon-Chavez D