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( d and e ) Neurons with different levels of endogenous -syn expression underwent the dual hit treatment regime with or without PFF treatment

Both DNA-binding and hypoxic activation of reporter genes using the ET-1 HBS was decreased compared with those for transferrin and erythropoietin HBSs

Author Contributions Authors equally contributed to research and preparation of the manuscript

Brenner provides outstanding, well-informed clinical direction

Mice in the Con group were fed a normal chow diet while those in the DM group were fed a high-fat diet (HFD, 60% kcal from fat, 20% kcal from protein, and 20% kcal from carbohydrate, Research Diets, NK) for 4 weeks to induce insulin resistance before being intraperitoneally injected with 40 mg/kg/day streptozotocin (STZ, Yuanye, China) for 3 days to induce partial insulin deficiency and hyperglycemia, mice with FBG 11.1 mmol/L were considered to be a successful model of diabetes

Their conclusion was that the value of steroids for idiopathic SSNHL remains unclear and the results of the randomized trials were contradictory