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To potentially prevent or slow down LA fragmentation by the brush-border enzymes responsible for LA fragmentation, chiral modification of the entire LA sequence to all D amino acids was conducted, which resulted in the generation of LA Analog 6 (A6) by Innovate Biopharmaceuticals, Inc

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the conduit was secured to both sides using two epineurial 100 nylon sutures (Fig

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This is consistent with our above data that sulindac can inhibit the activity of the PI3K/AKT/mTOR pathway, leading to a reduction in the phosphorylation of mTOR (p- mTOR), followed by the occurrence of autophagy