glutathione peroxidase 1 heme Scheme of HO-1-regulated ferroptosis. HO-1 plays a dual role in Regulation of inflammation by the

Antioxidant and hydration support

Mitochondrial electron transport chain complex II dysfunction causes premature aging of hematopoietic stem cells

129 However, it has also been reported that HMOX1 can induce cell death by promoting intracellular ferrous accumulation

Indications Skin radiance and pigmentation support Melasma adjunct Oxidative stress conditions Diabetic neuropathy (ALA component) Anti-ageing support Mechanism of Action L-Glutathione is the body's principal intracellular antioxidant

As an inhibitor of NRF2, Keap1 recognizes and binds to the ETGE and DLG motifs of NRF2 via its Kelch repeat domain, thereby continuously suppressing and promoting the degradation of NRF2 [87]

Although roFPs are highly sensitive to oxidative stress, their responses can be easily saturated (Fig