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The small molecule therapy crosses the blood-brain barrier and has showed efficacy against glioblastomas, including those resistant to the standard of care temozolomide ( TABLE 1 Current FDA Trials involving ONC201 (clinicaltrials.gov)

Springer International Publishing, Cham, pp 265273

This supercomplex in turn is thought to be activated by amino acids transported from the lysosomal lumen by transmembrane proteins, which in this way act as amino-acid sensors