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Wenzel-Seifert K, Wittmann M, Haen E

Moreover, iron from heme is necessary, while both Fe 2+ and Fe 3+ are sufficient to trigger ALIS formation (100)

J Biol Chem (2011) 286(36):318308

These enzymes are regulated independently, thereby avoiding the risk of a futile cycle (also known as a substrate cycle) that would result if both reactions occurred simultaneously at high rates