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1): Purified recombinant LhgO directly reduced ubiquinone (Supplementary Figure 7) in a L2HG-dependent manner with a specific activity of 0.33+/0.002 mol min 1 mg 1

Furthermore, it has been found that degradation of transcription factors such as nuclear erythroid 2 related factor (Nrf2) decreases expression of many antioxidant enzymes

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