glutathione increases the chelation process - an overview Glutathione Depletion and Stalwart Anticancer

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Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F

For example, the activation of inflammasomes, especially the NLRP3 inflammasome, leads to endothelial dysfunction, plaque formation, and myocardial injury by inducing the release of pro-inflammatory cytokines such as IL-1, IL-18, and IL-6 ( 5.1 The anti-inflammatory effect in atherosclerosis Silybin has been shown to reduce the inflammatory response in atherosclerotic lesions, with its core mechanism involving the direct inhibition of key pro-inflammatory signaling pathways

The above therapeutic effects were reversed after the transfection of si-Nrf2 in RA-FLSs to silence Nrf2 expression

Acta Pharmaceutica Sinica B 11(4):978988